RT Journal Article
T1 Cyclopropylmethyl Boronic Esters as General Reagents in Transition-Metal Catalyzed Homoallylation Reactions
A1 Lozano, Blanca
A1 Teresa, Javier
A1 Fernández López, Israel
A1 Tortosa, Mariola
AB Herein we disclose the use of cyclopropylmethyl boronates as general reagents in Negishi-type homoallylation reactions. This strategy provides a novel approach to generate enantioenriched homoallyl-Zn species through boron-to-zinc transmetalation. Subsequent sp2–sp3 cross-coupling offers a platform for the preparation of arenes, ketones, and 1,5-dienes containing a chiral homoallylic scaffold. The method has been applied to the late-stage functionalization of known drugs and the preparation of precursors of biologically relevant compounds. Mechanistic experiments and DFT calculations provide insight into the transmetalation/ring-opening sequence.
PB ACS
YR 2025
FD 2025-10-31
LK https://hdl.handle.net/20.500.14352/131542
UL https://hdl.handle.net/20.500.14352/131542
LA eng
NO Lozano, Blanca, et al. «Cyclopropylmethyl Boronic Esters as General Reagents in Transition-Metal Catalyzed Homoallylation Reactions». Journal of the American Chemical Society, vol. 147, n.o 45, noviembre de 2025, pp. 41221-28. DOI.org (Crossref), https://doi.org/10.1021/jacs.5c15781.
NO Ministerio de Ciencia, Innovación y Universidades
NO Agencia Estatal de Investigación (AEI)
NO European Research Council
DS Docta Complutense
RD 27 feb 2026