RT Journal Article
T1 Network disruption in the preclinical stages of Alzheimer’s Disease: from subjective cognitive decline to mild cognitive impairment
A1 López Sanz, David
A1 Garcés, Pilar
A1 Álvarez, Blanca
A1 Delgado Losada, María Luisa
A1 López Sánchez, Ramón
A1 Maestu Unturbe, Fernando
AB Introduction: Subjective Cognitive Decline (SCD) is a largely unknown state thought to represent a preclinical stage of Alzheimer’s Disease (AD) previous to mild cognitive impairment (MCI). However, the course of network disruption in these stages is scarcely characterized. Methods: We employed resting state magnetoencephalography in the source space to calculate network smallworldness, clustering, modularity and transitivity. Nodal measures (clustering and node degree) as well as modular partitions were compared between groups. Results: The MCI group exhibited decreased smallworldness, clustering and transitivity and increased modularity in theta and beta bands. SCD showed similar but smaller changes in clustering and transitivity, while exhibiting alterations in the alpha band in opposite direction to those showed by MCI for modularity and transitivity. At the node level, MCI disrupted both clustering and nodal degree while SCD showed minor changes in the latter. Additionally, we observed an increase in modular partition variability in both SCD and MCI in theta and beta bands. Conclusion: SCD elders exhibit a significant network disruption, showing intermediate values between HC and MCI groups in multiple parameters. These results highlight the relevance of cognitive concerns in the clinical setting and suggest that network disorganization in AD could start in the preclinical stages before the onset of cognitive symptoms.
PB World Scientific
SN 0129-0657
SN 1793-6462
YR 2017
FD 2017-11-02
LK https://hdl.handle.net/20.500.14352/102356
UL https://hdl.handle.net/20.500.14352/102356
LA eng
NO López-Sanz, D., Garcés, P., Álvarez, B., Delgado-Losada, M. L., López-Higes, R., & Maestú, F. (2017). Network disruption in the preclinical stages of Alzheimer’s disease: from subjective cognitive decline to mild cognitive impairment. International journal of neural systems, 27(08), 1750041.
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 21 abr 2025