RT Journal Article
T1 Lymphocyte integration of complement cues
A1 Marín Marín, Ana Victoria
A1 Cárdenas Mastrascusa, Paula Patricia
A1 Jiménez Reinoso, Anaïs
A1 Muñoz Ruiz, Miguel
A1 Regueiro González-Barros, José Ramón
AB We address current data, views and puzzles on the emerging topic of regulation of lymphocytes by complement proteins or fragments. Such regulation is believed to take place through complement receptors (CR) and membrane complement regulators (CReg) involved in cell function or protection, respectively, including intracellular signalling. Original observations in B cells clearly support that complement cues through CR improve their performance. Other lymphocytes likely integrate complement-derived signals, as most lymphoid cells constitutively express or regulate CR and CReg upon activation. CR-induced signals, particularly by anaphylatoxins, clearly regulate lymphoid cell function. In contrast, data obtained by CReg crosslinking using antibodies are not always confirmed in human congenital deficiencies or knock-out mice, casting doubts on their physiological relevance. Unsurprisingly, human and mouse complement systems are not completely homologous, adding further complexity to our still fragmentary understanding of complement-lymphocyte interactions.
PB Elsevier
SN 1084-9521
YR 2018
FD 2018-03-08
LK https://hdl.handle.net/20.500.14352/12715
UL https://hdl.handle.net/20.500.14352/12715
LA eng
NO Marín Marín, A. V., Cárdenas Mastrascusa, P. P., Jiménez Reinoso, A. et al. «Lymphocyte Integration of Complement Cues». Seminars in Cell & Developmental Biology, vol. 85, enero de 2019, pp. 132-42. DOI.org (Crossref), https://doi.org/10.1016/j.semcdb.2018.02.005.
NO Ministerio de Economía, Comercio y Empresa (España)
NO Comunidad de Madrid
NO Universidad Complutense de Madrid/Harvard University
DS Docta Complutense
RD 12 abr 2025