RT Journal Article
T1 Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV
A1 Notario Pérez, Fernando
A1 Martín Illana, Araceli
A1 Cazorla Luna, Raúl
A1 Ruiz Caro, Roberto
A1 Bedoya Del Olmo, Luis Miguel
A1 Tamayo, Aitana
A1 Rubio, Juan
A1 Veiga Ochoa, María Dolores
AB The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natural polymers that have good binding capacity with mucosal tissues, such as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose, or synthetic polymers such as Eudragit® RS. This paper assesses the potential of chitosan for the development of sustained-release vaginal tablets of Tenofovir and compares it with different polymers. The parameters assessed were the permanence time of the bioadhesion—determined ex vivo using bovine vaginal mucosa as substrate—the drug release profiles from the formulation to the medium (simulated vaginal fluid), and swelling profiles in the same medium. Chitosan can be said to allow the manufacture of tablets that remain adhered to the vaginal mucosa and release the drug in a sustained way, with low toxicity and moderate swelling that ensures the comfort of the patient and may be useful for the prevention of sexual transmission of HIV.
PB MDPI
SN 1660-3397
YR 2017
FD 2017-02-21
LK https://hdl.handle.net/20.500.14352/19232
UL https://hdl.handle.net/20.500.14352/19232
LA eng
NO Notario Pérez, F., Martín Illana, A., Cazorla Luna, R. et al. «Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV». Marine Drugs, vol. 15, n.o 2, febrero de 2017, p. 50. DOI.org (Crossref), https://doi.org/10.3390/md15020050.
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 30 dic 2025