RT Journal Article
T1 Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
A1 Vyšniauskas, Aurimas
A1 López Duarte, Ismael
A1 Duchemin, Nicolas
A1 Vu, Thanh-Truc
A1 Wu, Yilei
A1 Budynina, Ekaterina M.
A1 Volkova, Yulia A.
A1 Peña Cabrera, Eduardo
A1 Ramírez-Ornelas, Diana E.
A1 Kuimova, Marina K.
AB Microviscosity is a key parameter controlling the rate of diffusion and reactions on the microscale. Oneof the most convenient tools for measuring microviscosity is by fluorescent viscosity sensors termed‘molecular rotors’. BODIPY-based molecular rotors in particular proved extremely useful in combinationwith fluorescence lifetime imaging microscopy, for providing quantitative viscosity maps of living cells aswell as measuring dynamic changes in viscosity over time. In this work, we investigate several newBODIPY-based molecular rotors with the aim of improving on the current viscosity sensing capabilitiesand understanding how the structure of the fluorophore is related to its function. We demonstrate thatdue to subtle structural changes, BODIPY-based molecular rotors may become sensitive to temperatureand polarity of their environment, as well as to viscosity, and provide a photophysical model explainingthe nature of this sensitivity. Our data suggests that a thorough understanding of the photophysicsof any new molecular rotor, in environments of different viscosity, temperature and polarity, is a mustbefore moving on to applications in viscosity sensing.
PB Royal Society of Chemistry
SN 1463-9076
SN 1463-9084
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/114926
UL https://hdl.handle.net/20.500.14352/114926
LA eng
NO Vyšniauskas A, López-Duarte I, Duchemin N, Vu TT, Wu Y, Budynina EM, et al. Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors. Phys Chem Chem Phys [Internet]. 2017 [citado 17 de enero de 2025];19(37):25252-9. Disponible en: https://xlink.rsc.org/?DOI=C7CP03571C
NO European Commission-ERC
DS Docta Complutense
RD 18 mar 2026