RT Journal Article
T1 Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery
A1 Dumontel, Bianca
A1 Conejo Rodríguez, Verónica
A1 Vallet Regí, María Dulce Nombre
A1 Manzano García, Miguel
AB In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with different types of responsive pore gatekeepers have shown great potential for the formulation of drug delivery systems (DDS) with minimal premature leakage and site-specific controlled release. New nanotechnological approaches have been developed with the objective of utilizing natural biopolymers as smart materials in drug delivery applications. Natural biopolymers are sensitive to various physicochemical and biological stimuli and are endowed with intrinsic biodegradability, biocompatibility, and low immunogenicity. Their use as biocompatible smart coatings has extensively been investigated in the last few years. This review summarizes the MSNs coating procedures with natural polysaccharides and protein-based biopolymers, focusing on their application as responsive materials to endogenous stimuli. Biopolymer-coated MSNs, which conjugate the nanocarrier features of mesoporous silica with the biocompatibility and controlled delivery provided by natural coatings, have shown promising therapeutic outcomes and the potential to emerge as valuable candidates for the selective treatment of various diseases.
PB MDPI
SN 1999-4923
YR 2023
FD 2023-01-29
LK https://hdl.handle.net/20.500.14352/111914
UL https://hdl.handle.net/20.500.14352/111914
LA eng
NO Dumontel, B.; Conejo-Rodríguez, V.; Vallet-Regí, M.; Manzano, M. Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery. Pharmaceutics 2023, 15, 447. https://doi.org/10.3390/pharmaceutics15020447
NO 2023 Descuento MDPI
NO European Commision
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 9 abr 2025