RT Journal Article
T1 Copy Number Variation Regions Differing in Segregation Patterns Span Different Sets of Genes
A1 Arias, Katherine D.
A1 Gutiérrez García, Juan Pablo
A1 Fernández, Iván
A1 Álvarez, Isabel
A1 Goyache, Félix
AB Copy number variations regions (CNVRs) can be classified either as segregating, when found in both parents, and offspring, or non-segregating. A total of 65 segregating and 31 non-segregating CNVRs identified in at least 10 individuals within a dense pedigree of the Gochu Asturcelta pig breed was subjected to enrichment and functional annotation analyses to ascertain their functional independence and importance. Enrichment analyses allowed us to annotate 1018 and 351 candidate genes within the bounds of the segregating and non-segregating CNVRs, respectively. The information retrieved suggested that the candidate genes spanned by segregating and non-segregating CNVRs were functionally independent. Functional annotation analyses allowed us to identify nine different significantly enriched functional annotation clusters (ACs) in segregating CNVR candidate genes mainly involved in immunity and regulation of the cell cycle. Up to five significantly enriched ACs, mainly involved in reproduction and meat quality, were identified in non-segregating CNVRs. The current analysis fits with previous reports suggesting that segregating CNVRs would explain performance at the population level, whereas non-segregating CNVRs could explain between-individuals differences in performance.
PB MDPI
YR 2023
FD 2023-07-19
LK https://hdl.handle.net/20.500.14352/103971
UL https://hdl.handle.net/20.500.14352/103971
LA eng
NO Arias, K. D., Gutiérrez, J. P., Fernández, I., Álvarez, I., & Goyache, F. (2023). Copy Number Variation Regions Differing in Segregation Patterns Span Different Sets of Genes. Animals : an open access journal from MDPI, 13(14), 2351. https://doi.org/10.3390/ani13142351
NO 2022 Descuento MDPI
NO European Commission
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 2 oct 2024