RT Journal Article
T1 Structural Maintenance of Chromosomes 5/6 Complex Is Necessary for Tetraploid Genome Stability in Arabidopsis thaliana
A1 Yang, Fen
A1 Fernández Jiménez, Nadia
A1 Majka, Joanna
A1 Pradillo Orellana, Mónica
A1 Pecinka, Ales
AB Polyploidization is a common phenomenon in the evolution of flowering plants. However, only a few genes controlling polyploid genome stability, fitness, and reproductive success are known. Here, we studied the effects of loss-of-function mutations in NSE2 and NSE4A subunits of the Structural Maintenance of Chromosomes 5/6 (SMC5/6) complex in autotetraploid Arabidopsis thaliana plants. The diploid nse2 and nse4a plants show partially reduced fertility and produce about 10% triploid offspring with two paternal and one maternal genome copies. In contrast, the autotetraploid nse2 and nse4a plants were almost sterile and produced hexaploid and aneuploid progeny with the extra genome copies or chromosomes coming from both parents. In addition, tetraploid mutants had more severe meiotic defects, possibly due to the presence of four homologous chromosomes instead of two. Overall, our study suggests that the SMC5/6 complex is an important player in the maintenance of tetraploid genome stability and that autotetraploid Arabidopsis plants have a generally higher frequency of but also higher tolerance for aneuploidy compared to diploids.
PB Frontiers Media
SN 1664-462X
YR 2021
FD 2021-10-05
LK https://hdl.handle.net/20.500.14352/4875
UL https://hdl.handle.net/20.500.14352/4875
LA eng
NO Unión Europea. Horizonte 2020
NO Fondo Europeo de Desarrollo Regional (FEDER)
NO Ministerio de Educación, Cultura y Deporte
NO Ministry of Education Youth and Sports (Czechia)
NO Czech Academy of Sciences
NO China Scholarship Council Fellowship
NO Palacký University  (Olomouc, Czechia)
DS Docta Complutense
RD 18 abr 2025