RT Journal Article
T1 Successful oral prime‐immunization with VP60 from rabbit haemorrhagic disease virus produced in transgenic plants using different fusion strategies
A1 Gil Dones, Félix
A1 Titarenko, Elena
A1 Terrada, Estela
A1 Arcalís, Elsa
A1 Escribano, José
AB Expression levels of vaccine antigens in transgenic plants have important consequences in their use as edible vaccines. The major structural protein VP60 from the rabbit haemorrhagic disease virus (RHDV) has been produced in transgenic plants using different strategies to compare its accumulation in plant tissues. The highest expressing plants were those presenting stable, complex, high-density structures formed by VP60, suggesting the importance of multisubunit structures for the stability of this protein in plant cells. Mice fed with leaves of transgenic plants expressing VP60 were primed to a subimmunogenic baculovirus-derived vaccine single dose. This indicates that plants expressing VP60 antigen may be a new means for oral RHDV immunization.
PB Wiley
SN 1467-7644
YR 2005
FD 2005
LK https://hdl.handle.net/20.500.14352/94448
UL https://hdl.handle.net/20.500.14352/94448
LA eng
NO Gil, Félix, et al. «Successful Oral Prime‐immunization with VP60 from Rabbit Haemorrhagic Disease Virus Produced in Transgenic Plants Using Different Fusion Strategies». Plant Biotechnology Journal, vol. 4, n.o 1, enero de 2006, pp. 135-43. https://doi.org/10.1111/j.1467-7652.2005.00172.x.
NO This work was supported by Programa Sectorial de Biotecnología BIO2001-0370 and Programa de Recursos y Tecnologías Agrarias RTA01-057
NO Ministerio de Industria y Turismo (España)
DS Docta Complutense
RD 21 abr 2025