RT Journal Article
T1 LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later
A1 Betancor, Diana
A1 Gomez Lopez, Alicia
A1 Villalobos Vilda, Carlos
A1 Nuñez Borque, Emilio
A1 Fernández Bravo, Sergio
A1 De las Heras Gozalo, Manuel
A1 Pastor Vargas, Carlos
A1 Esteban, Vanesa
A1 Cuesta Herranz, Javier
AB Introduction: Allergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high cross-reactivity but extremely variable clinical expression. Little is known about the natural evolution of this allergy, which complicates management. The objective of this study was to assess the development of allergy to new plant foods in nsLTP-sensitized patients 10 years after diagnosis. Methods: One hundred fifty-one patients showing specific IgE to nsLTP determined by ISAC (Thermofisher) were included. After clinical workup (i.e., anamnesis, skin test, and challenge when needed), these patients were divided into two groups: 113 patients allergic to one or more plant food (74.5%) and 38 patients not allergic to any plant food (25.1%). Ten years later, a telephone interview was conducted to check whether patients had developed additional allergic reactions to plant foods. Results: Ten years after diagnosis, 35 of the 113 (31%) plant-food-allergic patients sensitized to nsLTP reported reactions to new, previously tolerated plant foods, mainly Rosaceae/Prunoideae fruits and nuts followed by vegetables, Rosacea/Pomoideae fruits, legumes, and cereals. Five out of 38 (13.2%) patients previously sensitized to nsLTP but without allergy to any plant food had experienced allergic reactions to some plant food: two to Rosaceae/Prunoideae fruits, two to Rosaceae/Prunoideae fruit and nuts, and one to legumes. Conclusion: Patients sensitized to nsLTP developed allergic reactions to other plant foods, mainly Rosaceae-Prunoideae fruits and nuts. This was more frequent among plant-food-allergic patients than among those who had never had plant-food allergy.
PB MPDI
SN 2072-6643
YR 2021
FD 2021-06-24
LK https://hdl.handle.net/20.500.14352/7045
UL https://hdl.handle.net/20.500.14352/7045
LA eng
NO Instituto de Salud Carlos III (ISCIII)/FEDER
NO Comunidad de Madrid
DS Docta Complutense
RD 6 jul 2025