RT Journal Article
T1 Xerostomia and Salivary Dysfunction in Patients With Diabetes Mellitus. A Cross-Sectional Study
A1 Sanchez Garrido, Isabel
A1 Ramírez Sanz, Lucía
A1 Muñoz Corcuera, Marta
A1 Garrido, Estela
A1 Sánchez, Lorenzo
A1 Martínez Acitores, María Luisa
A1 Hernández Vallejo, Gonzalo
A1 López-Pintor Muñoz, Rosa María
AB Background: Diabetes mellitus (DM) has been associated with salivary disorders such as xerostomia and hyposalivation. The aim of this study was to determine the prevalence of these disorders and their risk factors in DM patients.Methods: DM patients from two health centers were included. Epidemiological and DM control-related variables were collected. Xerostomia Inventory was filled out by the patients and unstimulated whole salivary flow was collected. Logistic regression tests were performed.Results: A total of 168 patients were included (46.4% men, 53.6% women, mean age 72.54 [SD 11.03 years]). Thirteen patients had Type 1 DM and 155 had Type 2 DM. 52.4% experienced xerostomia and 41.1% had unstimulated whole salivary flow hyposalivation. Women were more likely to suffer hyposalivation than men (OR 2.5, 95% CI 1.32-4.73; p = 0.005). Patients with T2DM were less likely to suffer UWS hyposalivation than T1DM patients (OR 0.28, 95% CI 0.08-0.95; p = 0.04). Glycemic control was not significantly worse in patients with xerostomia and hyposalivation. The drugs for the treatment of DM were not associated with salivary disorders. However, some drugs to treat other comorbidities such hypertension and neurological diseases were associated with xerostomia and hyposalivation.Conclusions: The prevalence of xerostomia and unstimulated whole salivary flow hyposalivation in patients with DM is high. Female sex, T1DM, and the use of certain non-antidiabetic drugs increased the risk of suffering these disorders. The possible association between DM, xerostomia, and/or hyposalivation is complex and may be influenced by multiple factors. Therefore, further studies are needed to evaluate whether DM influences these salivary disorde
PB Wiley
SN 0904-2512
YR 2024
FD 2024-09-30
LK https://hdl.handle.net/20.500.14352/109305
UL https://hdl.handle.net/20.500.14352/109305
LA eng
NO Sánchez Garrido I, Ramírez L, Muñoz Corcuera M, Garrido E, Sánchez L, Martínez Acitores ML, Hernández G, López-Pintor RM. Xerostomia and Salivary Dysfunction in Patients With Diabetes Mellitus. A Cross-Sectional Study. J Oral Pathol Med. 2024 Sep 29. doi: 10.1111/jop.13583. Epub ahead of print. PMID: 39343735.
DS Docta Complutense
RD 5 abr 2025