RT Journal Article
T1 Inflammatory activation and cholinergic anti-inflammatory system in eating disorders
A1 Güemes, Itziar
A1 Rodríguez, Alberto
A1 Mac-Dowell Mata, Karina Soledad
A1 Díaz Marsa, Marina Francisca
A1 Leza Cerro, Juan Carlos
A1 Carrasco Perera, José Luis
AB Dysfunctional serotoninergic regulation and hypothalamic-pituitary-adrenal (HPA) axis overreactivity have been consistently reported in research studies with eating disorders (ED). In addition, the links between stress response, serotonin function, HPA axis and inflammatory mechanisms in ED have also been suggested in a number of studies. In our study, inflammatory parameters in white blood cells were investigated in 26 female patients with ED and 25 healthy control subjects matched for sex, age and ethnicity. Patients were free of medication for at least two weeks at the time of the study. Results showed a significant increase in plasma levels of the proinflammatory cytokine IL1β and the protein expression of cyclooxygenase 2 (COX2) in peripheral mononuclear blood cells (PMBCs) in ED patients compared with controls. As well as a significant increase of the oxidative-nitrosative marker TBARS (Thiobarbituric Acid Reactive Substances) in plasma. These findings were associated with increased expression of the alpha7 subunit of the nicotinic receptor (α7nAChR) in PMBC in ED patients independent of plasma cotinine levels. These results suggest that a pro-inflammatory and oxidant phenotype might be present in ED patients. Further research on cellular inflammatory and anti-inflammatory pathways might be oriented to investigate differences between ED subtypes and to search for new potential targets for pharmacological treatment.
PB Elsevier
SN 0889-1591
YR 2013
FD 2013-08
LK https://hdl.handle.net/20.500.14352/96745
UL https://hdl.handle.net/20.500.14352/96745
LA eng
NO MacDowell KS, Díaz-Marsá M, Güemes I, Rodríguez A, Leza JC, Carrasco JL. Inflammatory activation and cholinergic anti-inflammatory system in eating disorders. Brain Behav Immun. 2013 Aug;32:33-9. doi: 10.1016/j.bbi.2013.04.006. PMID: 23624297.
NO Instituto de Salud Carlos III
NO CIBERSAM
DS Docta Complutense
RD 28 sept 2024