RT Journal Article
T1 Functional Connectivity Hypersynchronization in Relatives of Alzheimer’s Disease Patients: An Early E/I Balance Dysfunction?
A1 Ramírez Toraño, Federico
A1 Bruña Fernández, Ricardo
A1 De Frutos Lucas, Jaisalmer
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Marcos de Pedro, Silvia
A1 Delgado Losada, María Luisa
A1 Gómez Ruiz, N
A1 Barabash Bustelo, Ana
A1 Marcos Dolado, Alberto
A1 López Higes, Ramón
A1 Maestu Unturbe, Fernando
AB Alzheimer’s disease (AD) studies on animal models, and humans showed a tendency of the brain tissue to become hyperexcitable and hypersynchronized, causing neurodegeneration. However, we know little about either the onset of this phenomenon or its early effects on functional brain networks. We studied functional connectivity (FC) on 127 participants (92 middle-age relatives of AD patients and 35 age-matched nonrelatives) using magnetoencephalography. FC was estimated in the alpha band in areas known both for early amyloid accumulation and disrupted FC in MCI converters to AD. We found a frontoparietal network (anterior cingulate cortex, dorsal frontal, and precuneus) where relatives of AD patients showed hypersynchronization in high alpha (not modulated by APOE-ε4 genotype) in comparison to age-matched nonrelatives. These results represent the first evidence of neurophysiological events causing early network disruption in humans, opening a new perspective for intervention on the excitation/inhibition unbalance.
PB Oxford University Press
SN 1460-2199
YR 2020
FD 2020-10-27
LK https://hdl.handle.net/20.500.14352/100361
UL https://hdl.handle.net/20.500.14352/100361
LA eng
NO Ramírez-Toraño F, Bruña R, de Frutos-Lucas J, Rodríguez-Rojo IC, Marcos de Pedro S, Delgado-Losada ML, Gómez-Ruiz N, Barabash A, Marcos A, López Higes R, Maestú F. Functional Connectivity Hypersynchronization in Relatives of Alzheimer's Disease Patients: An Early E/I Balance Dysfunction? Cereb Cortex. 2021 Jan 5;31(2):1201-1210. doi: 10.1093/cercor/bhaa286
NO Ministerio de Economía y Competitividad
NO Comunidad de Madrid
NO Fundación La Caixa
DS Docta Complutense
RD 18 jul 2024