%0 Journal Article
%A Paz-Graniel, Indira
%A Valle-Hita, Cristina
%A Babio, Nancy
%A Serra-Majem, Lluís
%A Vioque, Jesus
%A Zomeño, María Dolores
%A Corella, Dolores
%A Pintó, Xavier
%A Cano-Ibáñez, Naomi
%A Tur, Josep A.
%A Cuadrado Soto, Esther
%A Martínez, J.A.
%A Díaz-López, Andrés
%A Torres-Collado, Laura
%A Goday, Albert
%A Fernández-Carrión, Rebeca
%A Nissenshon, Mariela
%A Riera-Mestre, Antoni
%A Garrido-Garrido, Eva
%A Bouzas, Cristina
%A Abete, Itziar
%A Daimiel, Lidia
%A Cornejo-Pareja, Isabel
%A Vázquez-Ruiz, Zenaida
%A Khoury, Nadine
%A Pérez-Vega, Karla Alejandra
%A Salas-Salvadó, Jordi
%T Long-term association between water intake and kidney function in a population at high cardiovascular risk
%D 2024
%@ 1279-7707
%U https://hdl.handle.net/20.500.14352/122492
%X Objectives: The evidence on water intake in the prevention of kidney function decline is scarce at population level in well-being individuals at high cardiovascular risk. Therefore, we aimed to longitudinally evaluate the associations between total water intake and subtypes and kidney function, through estimated-Glomerular Filtration Rate (eGFR). Methods: Three-year prospective analysis conducted in 1986 older adults (aged 55–75 year) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus study. Water intake was assessed using validated beverage and food frequency questionnaires. Serum creatinine-based eGFR (SCr-based eGFR; ml/min/1.73 m2 ) was estimated using the CKD-EPI equation at baseline, one-year and 3-years of follow-up. Mixed-effects linear regression models were fitted to evaluate the associations between baseline total water intake and subtypes, and SCr-based eGFR over 3-years of follow-up.Results: Participants in the highest baseline tertile of total water intake, plain water and water from all fluids showed a lower decrease in SCr-based eGFR after 3-years of follow-up, compared to those in the lowest tertile. Participants with the highest tap water consumption showed a lower SCr-based eGFR decline after 1-year and 3-years of followup, in comparerd to participants in the lowest intake category (T3 vs. T1:b: 1.4 ml/min/1.73 m2 ; 95%CI: 0.5–2.3,b: 1.0; 95%CI: 0.1–2.0, respectively). Conclusions: Plain water rather than other water sources, and especially tap water, was associated with lower kidney function decline assessed through eGFR over 3-years of follow-up, in older individuals at high cardiovascular risk.
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