RT Journal Article
T1 Long-term association between water intake and kidney function in a population at high cardiovascular risk
A1 Paz-Graniel, Indira
A1 Valle-Hita, Cristina
A1 Babio, Nancy
A1 Serra-Majem, Lluís
A1 Vioque, Jesus
A1 Zomeño, María Dolores
A1 Corella, Dolores
A1 Pintó, Xavier
A1 Cano-Ibáñez, Naomi
A1 Tur, Josep A.
A1 Cuadrado Soto, Esther
A1 Martínez, J.A.
A1 Díaz-López, Andrés
A1 Torres-Collado, Laura
A1 Goday, Albert
A1 Fernández-Carrión, Rebeca
A1 Nissenshon, Mariela
A1 Riera-Mestre, Antoni
A1 Garrido-Garrido, Eva
A1 Bouzas, Cristina
A1 Abete, Itziar
A1 Daimiel, Lidia
A1 Cornejo-Pareja, Isabel
A1 Vázquez-Ruiz, Zenaida
A1 Khoury, Nadine
A1 Pérez-Vega, Karla Alejandra
A1 Salas-Salvadó, Jordi
AB Objectives: The evidence on water intake in the prevention of kidney function decline is scarce at population level in well-being individuals at high cardiovascular risk. Therefore, we aimed to longitudinally evaluate the associations between total water intake and subtypes and kidney function, through estimated-Glomerular Filtration Rate (eGFR). Methods: Three-year prospective analysis conducted in 1986 older adults (aged 55–75 year) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus study. Water intake was assessed using validated beverage and food frequency questionnaires. Serum creatinine-based eGFR (SCr-based eGFR; ml/min/1.73 m2 ) was estimated using the CKD-EPI equation at baseline, one-year and 3-years of follow-up. Mixed-effects linear regression models were fitted to evaluate the associations between baseline total water intake and subtypes, and SCr-based eGFR over 3-years of follow-up.Results: Participants in the highest baseline tertile of total water intake, plain water and water from all fluids showed a lower decrease in SCr-based eGFR after 3-years of follow-up, compared to those in the lowest tertile. Participants with the highest tap water consumption showed a lower SCr-based eGFR decline after 1-year and 3-years of followup, in comparerd to participants in the lowest intake category (T3 vs. T1:b: 1.4 ml/min/1.73 m2 ; 95%CI: 0.5–2.3,b: 1.0; 95%CI: 0.1–2.0, respectively). Conclusions: Plain water rather than other water sources, and especially tap water, was associated with lower kidney function decline assessed through eGFR over 3-years of follow-up, in older individuals at high cardiovascular risk.
PB Elsevier
SN 1279-7707
YR 2024
FD 2024-09
LK https://hdl.handle.net/20.500.14352/122492
UL https://hdl.handle.net/20.500.14352/122492
LA eng
NO Paz-Graniel, I., Valle-Hita, C., Babio, N., Serra-Majem, L., Vioque, J., Zomeño, M. D., Corella, D., Pintó, X., Cano-Ibáñez, N., Tur, J. A., Cuadrado-Soto, E., Martínez, J. A., Díaz-López, A., Torres-Collado, L., Goday, A., Fernández-Carrión, R., Nissenshon, M., Riera-Mestre, A., Garrido-Garrido, E., Bouzas, C., … Salas-Salvadó, J. (2024). Long-term association between water intake and kidney function in a population at high cardiovascular risk. The journal of nutrition, health & aging, 28(9), 100327. https://doi.org/10.1016/j.jnha.2024.100327
DS Docta Complutense
RD 18 dic 2025