RT Journal Article
T1 Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-κB Pathways
A1 Olmedo, Dionisio A.
A1 López-Pérez, José Luis
A1 del Olmo, Esther
A1 Bedoya Del Olmo, Luis Miguel
A1 Sancho, Rocío
A1 Alcamí, José
A1 Muñoz, Eduardo
A1 San Feliciano, Arturo
A1 Gupta, Mahabir P.
AB Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2 one derivatives showed HIV transcriptional inhibitory activity but only the phenylchrome-2-one 10 inhibited NF-κB and displayed anti-Tat activity simultaneously. Compounds 10, 14, and 25, inhibited HIV replication in both targets at concentrations <25 µM. The assays of these synthetic 4 phenylchromen-2-ones may aid in the investigation of some aspects of the anti-HIV activity of such compounds and could serve as a scaffold for designing better anti-HIV compounds, which may lead to a potential anti-HIV therapeutic drug.
PB MDPI
SN 1420-3049
YR 2017
FD 2017-02-19
LK https://hdl.handle.net/20.500.14352/19242
UL https://hdl.handle.net/20.500.14352/19242
LA eng
NO Olmedo, D. A., López-Pérez, J. L., Del Olmo, E. et al. «Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-κB Pathways». Molecules, vol. 22, n.o 2, febrero de 2017, p. 321. DOI.org (Crossref), https://doi.org/10.3390/molecules22020321.
NO Ministerio de Economía, Comercio y Empresa (España)/Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional
NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional
DS Docta Complutense
RD 7 abr 2025