RT Journal Article
T1 Animal models for liver disease – A practical approach for translational research
A1 Nevzorova, Yulia
A1 Boyer Díaz, Zoe
A1 Cubero Palero, Francisco Javier
A1 Gracia Sancho, Jordi
AB Animal models are crucial for improving our understanding of human pathogenesis, enabling researchers to identify therapeutic targets and test novel drugs. In the current review, we provide a comprehensive summary of the most widely used experimental models of chronic liver disease, starting from early stages of fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, advanced cirrhosis and end-stage primary liver cancer. We focus on aspects such as reproducibility and practicality, discussing the advantages and weaknesses of available models for researchers who are planning to perform animal studies in the near future. Additionally, we summarise current and prospective models based on human tissue bioengineering.
PB Elsevier
SN 0168-8278
YR 2020
FD 2020-04-21
LK https://hdl.handle.net/20.500.14352/6373
UL https://hdl.handle.net/20.500.14352/6373
LA eng
NO Nevzorova, Y. A., Boyer Díaz, Z., Cubero Palero, F: J., & Gracia Sancho, J. «Animal Models for Liver Disease – A Practical Approach for Translational Research». Journal of Hepatology, vol. 73, n.o 2, agosto de 2020, pp. 423-40. DOI.org (Crossref), https://doi.org/10.1016/j.jhep.2020.04.011.
NO Ministerio de Ciencia, Innovación y Universidades (España)/Instituto de Salud Carlos III
NO Ministerio de Ciencia, Innovación y Universidades(España)/Programa Ramón y Cajal
NO European Foundation for Alcohol Research
NO Universidad Complutense de Madrid
NO European Cooperation in Science and Technology
NO Generalitat de Cataluña/Fondo Europeo de Desarrollo Regional
NO German Research Foundation
NO Swiss National Science Foundation
NO Swiss Foundation Against Liver Cancer
NO Swiss Foundation for Liver Diseases
NO Novartis Foundation for medical-biological research
DS Docta Complutense
RD 9 abr 2025