RT Journal Article
T1 Assessment of protein folding potentials with an evolutionary method
A1 Sancho, David de
A1 Rey Gayo, Antonio
AB Many different protein folding potentials have been developed in the last decades, based upon knowledge of experimentally determined protein structures. Decoy-based techniques are frequently used to assess these force fields, but other methods can explore different features in the performance of the interaction schemes, thus helping in their evaluation. Here, we propose an evolutionary strategy to efficiently assess folding potentials. We apply it to three potentials with different characteristics, taken from the bibliography. A search for minimum energy protein topologies, treated as arrangements of rigid protein fragments, is performed. The method, applied to a set of helix bundle proteins, shows the different behavior of the studied potentials, providing a reasonably fast tool to evaluate their advantages and limitations.
PB American Institute of Physics
SN 0021-9606
YR 2006
FD 2006
LK https://hdl.handle.net/20.500.14352/92631
UL https://hdl.handle.net/20.500.14352/92631
LA eng
NO David de Sancho, Antonio Rey; Assessment of protein folding potentials with an evolutionary method. J. Chem. Phys. 7 July 2006; 125 (1): 014904. https://doi.org/10.1063/1.2210931
NO Ministerio de Ciencia y Tecnología (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 18 abr 2025