RT Journal Article
T1 Production  of MCM-41 nanoparticles with control of particle size and structural properties: optimizing operationalconditions during scale-up.
A1 Castillo Romero, Rafael
A1 Torre, Lorena de la
A1 García Ochoa, Félix
A1 Ladero Galán, Miguel
A1 Vallet Regí, María Dulce Nombre
AB The synthesis of MCM-41mesoporous silica nanoparticles (MSNs) of controlled sizes and porous structure has been performed at laboratory and pilot plant scales. Firstly, the effects of the main operating conditions (TEOS addition rate, nanoparticle maturation time, temperature, and CTAB concentration) on the synthesis at laboratory scale (1 L round-bottom flask) were studied via a Taguchi experimental design. Subsequently, a profound one-by-one study of the effects of temperature and CTAB to TEOS molar ratio allowed to set these variables in 60 ºC and 8, avoiding particle enlargement and deformation of the internal structure. The final runs were performed at pilot plant scale (5 L cylindrical thermostated reactor) to analyze stirring speed, type of impeller, TEOS addition rate and nanoparticle maturation time effects, confirming results at laboratory scale. Despite slight variations on the morphology of the nanoparticles, this methodology provided MSNs with adequate sizes and porosities for biomedical applications regardless of the reactor/scale. The process showed to be robust and reproducible using mild synthesis conditions (2 mLmin-1 TEOS addition rate, 400 rpm stirred by a Rushton turbine, 60 minutes maturation time, 60 ºC, 2 gL-1 CTAB, molar ratio TEOS/CTAB=8), providing prismatic short mesoporous 100-200 nm nanorods with non-connected 3 nm parallel mesopores.
PB MDPI
SN 1422-0067
YR 2020
FD 2020-10-24
LK https://hdl.handle.net/20.500.14352/6682
UL https://hdl.handle.net/20.500.14352/6682
LA eng
NO RESEARCH ID L-2854-2014  (Rafael Castillo Romero)ORCID 0000-0003-1957-3098 (Rafael Castillo Romero)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. Horizonte 2020
DS Docta Complutense
RD 28 abr 2024