%0 Journal Article
%A Zuluaga, Susana
%A Gutiérrez Uzquiza, Álvaro
%A Bragado, Paloma
%A Alvarez-Barrientos, Alberto
%A Benito De Las Heras, Manuel R.
%A Nebreda,  Angel R
%A Porras Gallo, María Almudena
%T p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum
%D 2007
%@ 0014-5793
%U https://hdl.handle.net/20.500.14352/92697
%X The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulates the association between Rac-1 and caveolin-1 in serum-deprived cardiomyocytes. This interaction depends on cell attachment and correlates with higher levels of active Rac-1. Actin organization might regulate the formation of Rac-1-caveolin-1 complexes. In contrast, the Rac-1-caveolin-1 interaction is almost undetectable in the presence of serum, where Rac-1 activity is negatively regulated by p38alpha. Our results indicate that p38alpha can differentially contribute to Rac-1 activation depending on the presence of serum.
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