RT Journal Article
T1 p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum
A1 Zuluaga, Susana
A1 Gutiérrez Uzquiza, Álvaro
A1 Bragado, Paloma
A1 Alvarez-Barrientos, Alberto
A1 Benito De Las Heras, Manuel R.
A1 Nebreda, Angel R
A1 Porras Gallo, María Almudena
AB The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulates the association between Rac-1 and caveolin-1 in serum-deprived cardiomyocytes. This interaction depends on cell attachment and correlates with higher levels of active Rac-1. Actin organization might regulate the formation of Rac-1-caveolin-1 complexes. In contrast, the Rac-1-caveolin-1 interaction is almost undetectable in the presence of serum, where Rac-1 activity is negatively regulated by p38alpha. Our results indicate that p38alpha can differentially contribute to Rac-1 activation depending on the presence of serum.
SN 0014-5793
YR 2007
FD 2007
LK https://hdl.handle.net/20.500.14352/92697
UL https://hdl.handle.net/20.500.14352/92697
LA eng
NO Fraguas-Sánchez AI, Fernández-Carballido A, Martin-Sabroso C, Torres-Suárez AI. Stability characteristics of cannabidiol for the design of pharmacological, biochemical and pharmaceutical studies. Journal of Chromatography B 2020;1150:122188. https://doi.org/10.1016/j.jchromb.2020.122188.
NO Ministerio de Sanidad (España)
NO Ministerio de Educación y Ciencia (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 1 jul 2024