RT Journal Article
T1 Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism
A1 Oblitas, Crhistian Mario
A1 Lago Rodríguez, Marta‐Olimpia
A1 López Rubio, Marina
A1 García Gámiz, Mercedes
A1 Zamora Trillo, Angielys
A1 Álvarez-Sala Walther, Luis Antonio
A1 Galeano Valle, Francisco
A1 Demelo Rodríguez, Pablo
AB IntroductionAnticoagulant therapy is critical for venous thromboembolism (VTE) management, though bleeding remains a major concern, ranging from mild to fatal events. This study aimed to assess the predictive value of cytokines for major bleeding in patients with acute pulmonary embolism (PE).MethodsIn this prospective, observational study, patients aged ≥ 18 years with acute PE were enrolled from April 2021 to September 2022 and followed for 30 days. Exclusion criteria included asymptomatic PE, VTE without PE, and chronic anticoagulation. Major bleeding was defined as bleeding that required ≥ 2 transfused units of red blood cells, occurred in critical areas, or was fatal. Blood samples were collected at diagnosis to measure IL‐6, IL‐1beta, IL‐8, IL‐10, and TNF‐alpha. Statistical analyses used bivariate and multivariate logistic regression (p < 0.05).ResultsOut of 191 patients (mean age 68.6 years, 52.9% male), 8.4% died, and 4.2% experienced major bleeding within 30 days. IL‐8 > 40 pg/mL and TNF‐alpha > 8.5 pg/mL were linked to major bleeding. IL‐8 > 40 pg/mL independently predicted early major bleeding (adjusted OR 9.40; 95% CI 1.38–63.69). Cox regression showed HRs of 12.60 for IL‐8 and 5.61 for TNF‐alpha.ConclusionHigh IL‐8 levels at diagnosis were predictive of major bleeding in acute PE patients. Further studies are required to confirm these findings.
PB Wiley
SN 0902-4441
YR 2025
FD 2025-01-18
LK https://hdl.handle.net/20.500.14352/133005
UL https://hdl.handle.net/20.500.14352/133005
LA eng
NO Oblitas CM, Lago-Rodríguez MO, López-Rubio M, García-Gámiz M, Zamora-Trillo A, Alvarez-Sala-Walther LA, Galeano-Valle F, Demelo-Rodríguez P. Role of Cytokines in Predicting Early Major Bleeding in Patients With Acute Pulmonary Embolism. Eur J Haematol. 2025 May;114(5):847-851. doi: 10.1111/ejh.14387
NO 2025 Acuerdos transformativos CRUE
DS Docta Complutense
RD 21 mar 2026