%0 Journal Article
%A Castaño Joaqui, Oscar Gabriel
%A Jiménez Ortega, Laura
%A Cerero Lapiedra, Rocío
%A Domínguez Gordillo, Adelaida Africa
%T Burning Mouth Syndrome Underlying Factors: a Roadmap From a Network Perspective
%D 2024
%@ 1354-523X
%U https://hdl.handle.net/20.500.14352/116575
%X Objective: To investigate the relationship between biological, psychological, and social factors underlying Burning Mouth Syndrome (BMS).Subjects and methods: A case (n = 40) and control (n = 42) study containing 80 variables was examined using two network models based on regularized partial correlations (n = 82).Results: The structure of the associative pathways with the BMS was revealed. Direct associations involved Gastrointestinal Alterations (0.23), Vitamin D Deficiency (0.29), Musculoskeletal Alterations (0.29), Symptom Severity Score 2 (SSS2) (0.22), Cortisol Variation (0.10), Interpersonal Sensitivity (0.04), Hostility (0.03). Global Severity Index, Symptom Severity Score 1, Psychoticism, Obsession-Compulsion, Depression, Anxiety, and Somatization were indirectly related. The SSS2 was the most influential on BMS accuracy.Conclusions: Gastrointestinal alterations and vitamin D deficiency show a significant influence on BMS while cortisol mediates in multiple associative pathways between musculoskeletal alterations, gastrointestinal alterations, vitamin D deficiency, non-restorative sleep, fatigue, and cognitive problems. In addition to anxiety and depression, psychoticism, interpersonal sensitivity, and hostility stand out as psychological factors that seem to be related to a lack of vitamin D. None of the factors studied seem to have a relevant predictive potential for BMS, except for nonspecific symptoms of central sensitization.
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