RT Journal Article
T1 APOE ε4 modulation of training outcomes in several cognitive domains in a sample of cognitively intact older adults
A1 López Sánchez, Ramón
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Prados Atienza, José María
A1 Montejo, Pedro
A1 Del Río Grande, David Pedro
A1 Delgado Losada, María Luisa
A1 Montenegro Peña, María Mercedes
A1 López Sanz, David
A1 Barabash Bustelo, Ana
AB Background: Most research points to the  4 allele of the apolipoprotein E (APOE) gene as the most recognizable genetic risk factor associated with Alzheimer’s disease pathogenesis. It has been also suggested that the APOE  4 allele has a negative influence on cognitive functioning, which begins long before cognitive impairment becomes manifest. However, still, little is known about the APOE  4 interaction with cognitive intervention programs.Objective: The main goal of this study was to explore whether there was a differential APOE genotype modulation effect after cognitive training in different domains, such as language comprehension, executive functions, and memory. Contrary to other studies, hippocampal volume was controlled for. Methods: Fifty older adults (65+ years; 30 women and 20 men) participated in a multi-domain cognitive training that involved 30 sessions taking place over 12 weeks. Half of the participants were APOE  4 carriers. The control group was matched in age, gender, normalized hippocampal volume, cognitive reserve, Mini-Mental State Examination score, and Geriatric Depression Scale-Short Version.Results: The study revealed that there were consistent treatment benefits in complex sentence comprehension (noncanonical sentences and sentences with two propositions), a domain that was not directly trained, but only in the APOE  4 noncarrier group.Conclusion: Genetic profile modulates training outcomes in sentence comprehension.
PB Sage
SN 1387-2877
SN 1875-8908
YR 2017
FD 2017-06-23
LK https://hdl.handle.net/20.500.14352/102221
UL https://hdl.handle.net/20.500.14352/102221
LA eng
NO Lopez-Higes, R., Rodríguez-Rojo, I. C., Prados, J. M., Montejo, P., Del-Río, D., Delgado-Losada, M. L., ... & Barabash, A. (2017). APOE ε4 modulation of training outcomes in several cognitive domains in a sample of cognitively intact older adults. Journal of Alzheimer's Disease, 58(4), 1201-1215.
NO Ministerio de Economía y Competitividad (España)
NO Ministerio de Educación, Cultura y Deporte (España)
DS Docta Complutense
RD 9 abr 2025