RT Journal Article
T1 The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats
A1 Jiménez González, Sara
A1 Marín-Royo, Gema
A1 Jurado-López, Raquel
A1 Bartolomé, 
A1 Bartolomé Pascual, María Visitación
A1 Miranda-Romero, Ana
A1 Luaces Méndez, María
A1 Islas, Fabian
A1 Nieto, María Luisa
A1 Martínez-Martínez, 
A1 Martínez Martínez, Ernesto
A1 Cachofeiro, Victoria
A1 Cachofeiro Ramos, María Victoria
AB The impact of the mitochondria-targeted antioxidant MitoQ was evaluated in the cardiac alterations associated with obesity. Male Wistar rats were fed either a high fat diet (HFD, 35% fat) or a standard diet (CT, 3.5% fat) for 7 weeks and treated with MitoQ (200 µM). The effect of MitoQ (5 nM) in rat cardiac myoblasts treated for 24 h with palmitic acid (PA, 200 µM) was evaluated. MitoQ reduced cardiac oxidative stress and prevented the development of cardiac fibrosis, hypertrophy, myocardial 18-FDG uptake reduction, and mitochondrial lipid remodeling in HFD rats. It also ameliorated cardiac mitochondrial protein level changes observed in HFD: reductions in fumarate hydratase, complex I and II, as well as increases in mitofusin 1 (MFN1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha, and cyclophilin F (cycloF). In vitro, MitoQ prevented oxidative stress and ameliorated alterations in mitochondrial proteins observed in palmitic acid (PA)-stimulated cardiac myoblasts: increases in carnitine palmitoyltransferase 1A, cycloF, and cytochrome C. PA induced phosphorylation of extracellular signal-regulated kinases and nuclear factor-κB p65. Therefore, the data show the beneficial effects of MitoQ in the cardiac damage induced by obesity and suggests a crosstalk between lipotoxicity and mitochondrial oxidative stress in this damage
PB MDPI
SN 2073-4409
YR 2020
FD 2020-02-17
LK https://hdl.handle.net/20.500.14352/112856
UL https://hdl.handle.net/20.500.14352/112856
LA eng
NO Jiménez-González S, Marín-Royo G, Jurado-López R, Bartolomé MV, Romero-Miranda A, Luaces M, Islas F, Nieto ML, Martínez-Martínez E, Cachofeiro V. Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats.Cells. 2020 Feb 17;9(2):451. doi: 10.3390/cells9020451.
NO ISCIII
NO Ministerio de Economia y Competitividad
NO CAM
DS Docta Complutense
RD 18 abr 2025