RT Journal Article
T1 Enhancing Regulatory T Cells to Treat Inflammatory and Autoimmune Diseases
A1 Fiyouzi Alipour, Tara
A1 Peláez Prestel, Héctor Fernando
A1 Reyes Manzanas, Raquel
A1 Lafuente Duarte, María Esther
A1 Reche Gallardo, Pedro Antonio
A2 Renaudineau, Yves
AB Regulatory T cells (Tregs) control immune responses and are essential to maintain immune homeostasis and self-tolerance. Hence, it is no coincidence that autoimmune and chronic inflammatory disorders are associated with defects in Tregs. These diseases have currently no cure and are treated with palliative drugs such as immunosuppressant and immunomodulatory agents. Thereby, there is a great interest in developing medical interventions against these diseases based on enhancing Treg cell function and numbers. Here, we give an overview of Treg cell ontogeny and function, paying particular attention to mucosal Tregs. We review some notable approaches to enhance immunomodulation by Tregs with therapeutic purposes including adoptive Treg cell transfer therapy and discuss relevant clinical trials for inflammatory bowel disease. We next introduce ways to expand mucosal Tregs in vivo using microbiota and dietary products that have been the focus of clinical trials in various autoimmune and chronic-inflammatory diseases.
PB MDPI
SN 1422-0067
SN 1661-6596
YR 2023
FD 2023-04-25
LK https://hdl.handle.net/20.500.14352/92108
UL https://hdl.handle.net/20.500.14352/92108
LA eng
NO Fiyouzi, T., Peláez Prestel, H. F., Reyes Manzanas, R. et al. «Enhancing Regulatory T Cells to Treat Inflammatory and Autoimmune Diseases». International Journal of Molecular Sciences, vol. 24, n.o 9, abril de 2023, p. 7797. DOI.org (Crossref), https://doi.org/10.3390/ijms24097797.
NO Comunidad Autonoma de Madrid
DS Docta Complutense
RD 16 abr 2025