RT Journal Article
T1 Understanding the Episodic Memory and Executive Functioning Axis Impairment in MCI Patients: A Multicenter Study in Comparison with CSF Biomarkers
A1 Chino, Brenda
A1 Torres Simón, Lucía
A1 Zelwetro, Agnieszka
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Carnes Vendrell, Anna
A1 Piñol Ripoll, Gerard
A1 Yubero Pancorbo, Raquel
A1 Paul Lapedriza, Nuria Ascensión
A1 Maestu Unturbe, Fernando
AB Background: This study aimed to explore the association between a verbal learning task that evaluates the potential mutual dependency between memory and executive functions (i.e., the Test of Memory Strategies, TMS) and cerebrospinal fluid (CSF) Alzheimer’s Disease (AD) biomarkers. Methods: A sample of 47 mild cognitive impairment (MCI) participants from Poland and Spain were classified according to the Erlangen Score Diagnostic Algorithm (ESA) into CSF- (n = 16) and CSF+ (n = 31) groups. Correlation analyses between TMS word-list conditions and CSF biomarkers were conducted. Additionally, an analysis of covariance was performed to define the effect on ESA classification in the sample, using as a covariable the country of origin of the participants. Results: Significant associations between the TMS-3 condition and Aβ42, t-tau, and p-tau were observed for the whole sample. In addition, the CSF- participants obtained higher cognitive performance in TMS-3 compared to the CSF+ group. This outcome persisted if the groups were based on Aβ42 scores, but not t-tau or p-tau values. Conclusions: These findings could indicate that poor performance on verbal learning tests may be affected by executive dysfunctions. Therefore, future intervention plans focused on training executive functions would be of interest to improve the ability of MCI patients to encode and organize information.
PB MDPI
SN 2227-9059
YR 2023
FD 2023-11-26
LK https://hdl.handle.net/20.500.14352/110936
UL https://hdl.handle.net/20.500.14352/110936
LA eng
NO Chino, B., Torres Simón, L., Zelwetro, A., Rodríguez Rojo, I.C., Carnes Vendrell, A., Piñol Ripoll, G., Yubero, R., Paúl, N. & Maestú, F. Understanding the Episodic Memory and Executive Functioning Axis Impairment in MCI Patients: A Multicenter Study in Comparison with CSF Biomarkers. Biomedicines 2023, 11, 3147. https://doi.org/10.3390/biomedicines11123147
NO 2023 Descuento MDPI
DS Docta Complutense
RD 7 abr 2025