RT Journal Article
T1 AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus-Dependent Memory
A1 Parra Gonzalo, Juan De La
A1 Cuartero Desviat, María Isabel
A1 Pérez Ruiz, Alberto
A1 García Culebras, Alicia
A1 Martín Herranz, Ricardo
A1 Sánchez-Prieto Borja, José
A1 García Segura, Juan Manuel
A1 Lizasoaín Hernández, Ignacio
A1 Moro Sánchez, María Ángeles
AB Newborn granule cells are continuously produced in the subgranular zone of dentate gyrus throughout life. Once these cells mature, they integrate into pre-existing circuits modulating hippocampus-dependent memory. Subsequently, mechanisms controlling generation and maturation of newborn cells are essential for proper hippocampal function. Therefore, we have studied the role of aryl hydrocarbon receptor (AhR), a ligand-activated bHLH-PAS transcription factor, in hippocampus-dependent memory and granule neuronal morphology and function using genetic loss-of-function approaches based on constitutive and inducible-nestin AhR–/– mice. The results presented here show that the impaired hippocampus-dependent memory in AhR absence is not due to its effects on neurogenesis but to aberrant dendritic arborization and an increased spine density, albeit with a lower number of mature mushrooms spines in newborn granule cells, a finding that is associated with an immature electrophysiological phenotype. Together, our data strongly suggest that AhR plays a pivotal role in the regulation of hippocampal function, by controlling hippocampal granule neuron morphology and synaptic maturation.
PB Society for Neuroscience
SN 2373-2822
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/94497
UL https://hdl.handle.net/20.500.14352/94497
LA eng
NO De La Parra, Juan, et al. «AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus-Dependent Memory». Eneuro, vol. 5, n.o 4, julio de 2018, p. ENEURO.0370-17.2018.  https://doi.org/10.1523/ENEURO.0370-17.2018.
NO Ministerio de Economía y Competitividad (España)
NO European Commission
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 10 abr 2025