RT Journal Article
T1 Amine-functionalized mesoporous silica nanoparticles decorated by silver nanoparticles for delivery of doxorubicin in breast and cervical cancer cells
A1 Ghobadi, Melika
A1 Salehi, Saeideh
A1 Ardestani, Mohammad Taha Salmanifard
A1 Mousavi Khattat, Mohammad
A1 Shakeran, Zahra
A1 Khosravi, Arezoo
A1 Zarrabi, Ali
A1 Cordani, Marco
AB Nanocarriers have demonstrated promising potential in the delivery of various anticancer drugs and in improving the efficiency of the treatment. In this study, silver nanoparticles (AgNPs) were green-synthesized using the extracts of different parts of the pomegranate plant, including the peel, flower petals, and calyx. To obtain the most efficient extract used for the green synthesis of AgNPs, all three types of synthesized nanoparticles were characterized. Then, (3-Aminopropyl) triethoxysilane-functionalized mesoporous silica nanoparticles (MSNs-APTES) decorated with AgNPs were fabricated via a one-pot green-synthesis method. AgNPs were directly coated on the surface of MSNs-APTES by adding pomegranate extract enriched with a source of reducing agent leading to converting the silver ion to AgNPs. The MSN-APTES-AgNPs (MSNs-AgNPs) have been thoroughly characterized using nanoparticle characterization techniques. In addition, DNA cleavage and hemolysis activities of the synthesized nanoparticles were analyzed, confirming the biocompatibility of synthesized nanoparticles. The Doxorubicin (DOX, as a breast/cervical anti-cancer drug) loading (42.8%) and release profiles were investigated via UV-visible spectroscopy. The fibroblast, breast cancer, and cervical cancer cells' viability against DOX-loaded nanoparticles were also studied. The results of this high drug loading, uniform shape, and small functionalized nanoparticles demonstrated its great potential for breast and cervical cancer management.
PB Elsevier
SN 0939-6411
YR 2024
FD 2024-08
LK https://hdl.handle.net/20.500.14352/108769
UL https://hdl.handle.net/20.500.14352/108769
LA eng
NO Ghobadi M, Salehi S, Ardestani MTS, Mousavi-Khattat M, Shakeran Z, Khosravi A, Cordani M, Zarrabi A. Amine-functionalized mesoporous silica nanoparticles decorated by silver nanoparticles for delivery of doxorubicin in breast and cervical cancer cells. European Journal of Pharmaceutics and Biopharmaceutics [Internet]. 2024 [cited 2024 Oct 8];201:114349. doi: 10.1016/j.ejpb.2024.114349.
NO European Comission
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 11 abr 2025