RT Journal Article
T1 Chronic Consumption of Cocoa Rich in Procyanidins Has a Marginal Impact on Gut Microbiota and on Serum and Fecal Metabolomes in Male Endurance Athletes
A1 Larrosa Pérez, María Del Mar
A1 Tabone, Mariangela
A1 García-Merino, Jose Angel
A1 Bressa, Carlo
A1 Rocha-Guzmán, Nuria Elisabeth
A1 Herrera-Rocha, Karen
A1 Chu Van, Emeline
A1 Castelli, Florance
A1 Fenaille, François
AB Cocoa is used in the sports world as a supplement, although there is no consensus on its use. We investigated the effect of cocoa intake on intestinal ischemia (intestinal fatty acid-binding protein (I-FABP)), serum lipopolysaccharide (LPS) levels, gastrointestinal symptoms, and gut microbiota in endurance athletes during their training period on an unrestricted diet. We also performed a metabolomics analysis of serum and feces after a bout of exercise before and after supplementation. Cocoa consumption had no effect on I-FABP, LPS, or gastrointestinal symptoms. Cocoa intake significantly increased the abundance of Blautia and Lachnospira genera and decreased the abundance of the Agathobacter genus, which was accompanied by elevated levels of polyphenol fecal metabolites 4-hydroxy-5-(phenyl)-valeric acid and O-methyl-epicatechin-O-glucuronide. Our untargeted approach revealed that cocoa had no significant effects on serum and fecal metabolites and that its consumption had little impact on the metabolome after a bout of physical exercise.
PB American Chemical Society
YR 2022
FD 2022-02-16
LK https://hdl.handle.net/20.500.14352/115391
UL https://hdl.handle.net/20.500.14352/115391
LA eng
NO Tabone M, García-Merino JA, Bressa C, Rocha Guzman NE, Herrera Rocha K, Chu Van E, Castelli FA, Fenaille F, Larrosa M. Chronic Consumption of Cocoa Rich in Procyanidins Has a Marginal Impact on Gut Microbiota and on Serum and Fecal Metabolomes in Male Endurance Athletes. J Agric Food Chem. 2022;70(6):1878-1889
NO Ministerio Economía y Competitividad
NO European Molecular Biology Organization; EMBO, STF 8131
NO Ministerio de Educación, Cultura y Deporte, FPU grant 2016/01110
NO MetaboHUB infrastructure ANR-11-INBS- 0010 grant
DS Docta Complutense
RD 18 abr 2025