RT Journal Article
T1 In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
A1 Simeonidis, Konstantinos
A1 Puerto Morales Herrero, María Del
A1 Marciello, Marzia
A1 Angelakeris, Makis
A1 Presa Muñoz De Toro, Patricia Marcela De La
A1 Lázaro Carrillo, Ana
A1 Tabero Truchado, Andrea
A1 Villanueva Oroquieta, Ángeles
A1 Chubykalo-Fesenko, Oksana
A1 Serantes Abalo, David
AB Promising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of the nanoparticle performance in the cellular environment. This constitutes a huge research challenge due to difficulties for achieving a remote control within the human body. Here we report on the significant double role of the shape of ellipsoidal magnetic nanoparticles (nanorods) subjected to an external AC magnetic field: first, the heat release is increased due to the additional shape anisotropy; second, the rods dynamically reorientate in the orthogonal direction to the AC field direction. Importantly, the heating performance and the directional orientation occur in synergy and can be easily controlled by changing the AC field treatment duration, thus opening the pathway to combined hyperthermic/mechanical nanoactuators for biomedicine. Preliminary studies demonstrate the high accumulation of nanorods into HeLa cells whereas viability analysis supports their low toxicity and the absence of apoptotic or necrotic cell death after 24 or 48 h of incubation.
SN 2045-2322
YR 2016
FD 2016-12-06
LK https://hdl.handle.net/20.500.14352/100775
UL https://hdl.handle.net/20.500.14352/100775
LA eng
NO Simeonidis, Konstantinos, et al. «In-Situ Particles Reorientation during Magnetic Hyperthermia Application: Shape Matters Twice». Scientific Reports, vol. 6, n.o 1, diciembre de 2016, p. 38382. DOI.org (Crossref), https://doi.org/10.1038/srep38382.
NO Ministerio de Economía, Comercio y Empresa (España)
NO Comunidad de Madrid
NO EC FP-7 grant “NanoMag”
NO Xunta de Galicia
NO Universidad Autónoma de Madrid
DS Docta Complutense
RD 6 abr 2025