RT Journal Article
T1 Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
A1 Polo, Lorena
A1 Gómez Cerezo, María Natividad
A1 Aznar, Elena
A1 Vivancos, José-Luis
A1 Sancenón, Félix
A1 Arcos Navarrete, Daniel
A1 Vallet Regí, María Dulce Nombre
A1 Martínez-Máñez, Ramón
AB Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and ε-poly-l-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic (levofloxacin) and an antitumoral drug (doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments.
PB Elsevier
SN 1742-7061
YR 2017
FD 2017-03
LK https://hdl.handle.net/20.500.14352/96416
UL https://hdl.handle.net/20.500.14352/96416
LA eng
NO Polo L, Gómez-Cerezo N, Aznar E, Vivancos J-L, Sancenón F, Arcos D, et al. Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection. Acta Biomaterialia 2017;50:114–26. https://doi.org/10.1016/j.actbio.2016.12.025.
NO Gobierno de España
NO Generalitat Valenciana
NO European Research Council
DS Docta Complutense
RD 2 oct 2024