RT Journal Article
T1 Periodontal diseases and depression: A pre‐clinical in vivo study
A1 Martínez, María
A1 Martín‐Hernández, David
A1 Virto Ruiz, Leire
A1 Mac-Dowell Mata, Karina Soledad
A1 Leza Cerro, Juan Carlos
A1 García Bueno, Borja
A1 Figuero Ruiz, Elena
A1 Ambrosio Elejalde, Nagore
A1 Herrera González, David
A1 Montero Solís, Eduardo
A1 González Bris, Álvaro
A1 Marín Cuenda, María José
A1 Sanz Martín, Mariano
AB Aim: To analyse, through a pre-clinical in vivo model, the possible mechanisms linking depression and periodontitis at behavioural, microbiological and molecular levels.Materials and methods: Periodontitis (P) was induced in Wistar:Han rats (oral gavages with Porphyromonas gingivalis and Fusobacterium nucleatum) during 12 weeks, followed by a 3-week period of Chronic Mild Stress (CMS) induction. Four groups (n = 12 rats/group) were obtained: periodontitis and CMS (P+CMS+); periodontitis without CMS; CMS without periodontitis; and control. Periodontal clinical variables, alveolar bone levels (ABL), depressive-like behaviour, microbial counts and expression of inflammatory mediators in plasma and brain frontal cortex (FC), were measured. ANOVA tests were applied.Results: The highest values for ABL occurred in the P+CMS+ group, which also presented the highest expression of pro-inflammatory mediators (TNF-α, IL-1β and NF-kB) in frontal cortex, related to the lipoprotein APOA1-mediated transport of bacterial lipopolysaccharide to the brain and the detection of F. nucleatum in the brain parenchyma. A dysregulation of the hypothalamic-pituitary-adrenal stress axis, reflected by the increase in plasma corticosterone and glucocorticoid receptor levels in FC, was also found in this group.Conclusions: Neuroinflammation induced by F. nucleatum (through a leaky mouth) might act as the linking mechanism between periodontal diseases and depression.
PB Wiley
SN 0303-6979
SN 1600-051X
YR 2021
FD 2021-02-09
LK https://hdl.handle.net/20.500.14352/96806
UL https://hdl.handle.net/20.500.14352/96806
LA eng
NO Martínez M, Martín-Hernández D, Virto L, MacDowell KS, Montero E, González-Bris Á, Marín MJ, Ambrosio N, Herrera D, Leza JC, Sanz M, García-Bueno B, Figuero E. Periodontal diseases and depression: A pre-clinical in vivo study. J Clin Periodontol. 2021 Apr;48(4):503-527. doi: 10.1111/jcpe.13420. PMID: 33432590.
NO Santander-University Complutense of Madrid Projects
NO MINECO-FEDER
NO CIBERSAM
DS Docta Complutense
RD 18 jul 2024