RT Journal Article
T1 Targeted Chemo‐Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment
A1 Villaverde Cantizano, Gonzalo
A1 Gómez Graña, Sergio
A1 Guisasola, Eduardo
A1 García García, María Isabel
A1 Hanske, Cristoph
A1 Liz-Marzan, Luis M.
A1 Baeza, Alejandro
A1 Vallet Regí, María Dulce Nombre
AB Melanoma is one of the most severe public health issues worldwide, not onlybecause of the high number of cases but also for its poor prognosis in late stages. Therefore, early diagnosis and efficient treatment are key toward a future solution. However, melanoma is highly resistant to cytotoxicity in its metastatic form. In this context, we propose a therapeutic strategy based on a targeted chemo-photothermal nanotransporter for cytotoxic compounds. This approach comprises the use of core-multishell gold nanorods, coated with mesoporous silica and further covered with a thermosensitive polymer, which is vectorized for selective internalization in melanoma cells. The proposed nanoformulation is capable of releasing the transported cytotoxic compounds on demand, in response to near-IR irradiation, with high selectivity and efficacy against malignant cells, even at low concentrations, thereby providing a new tool against melanoma disease.
PB Wiley-VCH Verlag GMBH
SN 0934-0866
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/18634
UL https://hdl.handle.net/20.500.14352/18634
LA eng
NO Villaverde Cantizano, G., Gómez Graña, S., Guisasola, E. et al. «Targeted Chemo‐Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment». Particle & Particle Systems Characterization, vol. 35, n.o 7, julio de 2018, p. 1800148. DOI.org (Crossref), https://doi.org/10.1002/ppsc.201800148.
NO RESEARCHER ID L-2250-2014 (Gonzalo Villaverde Cantizano)ORCID 0000-0003-2065-0417 (Gonzalo Villaverde Cantizano)RESEARCHER ID G-7562-2016 (Sergio Gómez Graña)ORCID 0000-0002-7736-051X (Sergio Gómez Graña)RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)ORCID  0000-0002-2549-1745 (Eduardo Guisasola Cal)RESEARCHER ID K-8193-2014  (Alejandro Baeza)ORCID 0000-0002-2026-6266 (Alejandro Baeza)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 3 abr 2025