RT Journal Article
T1 Enhanced cortisol suppression in eating disorders with impulsive personality features
A1 Díaz Marsa, Marina Francisca
A1 Carrasco Perera, José Luis
A1 Basurte, Elena
A1 Sáiz Ruiz, Jerónimo
A1 López-Ibor Aliño, Juan José
A1 Hollander, Eric
AB Evidence of both blunted and enhanced cortisol suppression with the dexamethasone test (DST) is available in eating disorders (ED), suggesting that different subtypes of ED might be characterized by distinct neurobiological stress response dysfunctions. Other evidence indicates that ED patients with impulsive clinical features might have enhanced cortisol suppression similar to patients with impulsive personality disorders. A group of 52 patients with restrictive anorexia, binge eating-purging anorexia and bulimia nervosa were studied with a very low dose (0.25 mg) dexamethasone test and measures of phenomenology, personality and impulsivity. Patients with bulimic symptoms had significantly higher rates of cortisol suppression than controls and than restrictive anorectic patients. Percent cortisol suppression showed a strong and significant correlation with the patient's score on the Barratt Impulsiveness Scale. A hypersensitive cortisol response to dexamethasone, which might reflect hypothalamic-pituitary-adrenal axis dysfunctions might be specifically associated with impulsive subtypes of eating disorders.
PB Elsevier
SN 0165-1781
YR 2008
FD 2008-02
LK https://hdl.handle.net/20.500.14352/116903
UL https://hdl.handle.net/20.500.14352/116903
LA eng
NO Díaz-Marsá M, Carrasco JL, Basurte E, Sáiz J, López-Ibor JJ, Hollander E. Enhanced cortisol suppression in eating disorders with impulsive personality features. Psychiatry Res. 2008 Feb 28;158(1):93-7. doi: 10.1016/j.psychres.2007.06.020
DS Docta Complutense
RD 9 abr 2025