RT Journal Article
T1 Pyogenic liver abscesses in liver transplant recipients versus non-transplant population: Outcome and risk factors of patient survival
A1 Jiménez Romero, Luis Carlos
A1 Marcacuzco Quinto, Alberto Alejandro
A1 Caso Maestro, Óscar
A1 Lechuga, I.
A1 Manrique Municio, Alejandro
A1 García-Sesma Pérez-Fuentes, Álvaro
A1 Calvo, J.
A1 Aguado García, José María
A1 López Medrano, Francisco
A1 San Juan Garrido, Rafael
A1 Justo Alonso, Iago
AB Pyogenic liver abscess (PLA) is a life-threatening infection in both liver transplant (LT) and non-LT patients. Several risk factors, such as benign and malignant hepatopancreatobiliary diseases and colorectal tumors have been associated with PLA in the non-LT population, and hepatic artery stricture/thrombosis, biliary stricture, and hepaticojejunostomy in the LT patients. The objective of this study is to compare the outcomes of patients with PLA in LT and non-LT patients and to determine the risk factors associated with patient survival. From January 2000 to November 2020, a total of 296 adult patients were diagnosed of PLA in our institution, of whom 26 patients had previously undergone liver transplantation (LTA group), whereas 263 patients corresponded to the non-LTA population. Seven patients with PLA who had undergone previous kidney transplantation were excluded from this retrospective study. Twenty-six patients out of 1503 LT developed PLA (incidence of 1.7%). Median age was significantly higher in non-LTA patients (p =.001). No significant differences were observed in therapy. PLA recurrence was significantly higher in LTA than in non-LTA (34.6% vs. 14.8%; p =.008). In-hospital mortality was greater in the LT group than in the non-LT group (19.2% vs. 9.1% p =.10) and was identified in multivariable analysis as a risk factor for mortality (p =.027). Mortality rate during follow-up did not show significant differences between the groups: 34.6% in LTA patients versus 26.2% in non-LTA patients (p =.10). The most common causes of mortality during follow-up were malignancies, Covid-19 infection, and neurologic disease. 1-, 3-, and 5-year actuarial patient survival rates were 87.0%, 64.1%, and 50.4%, respectively, in patients of LTA group, and 84.5%, 66.5%, and 51.0%, respectively, in patients with liver abscesses in non-LTA population (p =.53). In conclusion, LT was a risk factor for in hospital mortality, but not during long-term follow-up.
PB Wiley
YR 2023
FD 2023-03-05
LK https://hdl.handle.net/20.500.14352/129816
UL https://hdl.handle.net/20.500.14352/129816
LA eng
NO Jiménez‐Romero, Carlos, et al. «Pyogenic Liver Abscesses in Liver Transplant Recipients versus Non‐transplant Population. Outcome and Risk Factors of Patient Survival». Clinical Transplantation, vol. 37, n.o 6, junio de 2023, p. e14966. DOI.org (Crossref), https://doi.org/10.1111/ctr.14966.
DS Docta Complutense
RD 11 ene 2026