RT Journal Article
T1 Coexpression of AT1 and AT2 receptors by human fibroblasts is associated with resistance to angiotensin II
A1 Galindo Izquierdo, María
A1 Santiago, Begoña
A1 Palao, Guillermo
A1 Gutiérrez Cañas, Irene
A1 Ramírez Fernández, Juan Carlos
A1 Pablos Álvarez, José Luis
AB Angiotensin II (AngII) is considered as a cytokine-like factor displaying a variety of proinflammatory and profibrotic cellular effects. Most of these effects seem mediated by AT1 signaling, whereas AT2 expression and function in adult human cells remain unclear. We have studied AT1 and AT2 expression in different human adult fibroblasts types and analyze their response to AngII. AngII did not induce thymidine incorporation, apoptosis nor collagen gene or protein expression in human fibroblasts. Specific AT1 or AT2 inhibitors did not modify this apparent resistance to AngII. We found abundant expression of both AT1 and AT2 receptors in all human fibroblasts studied, whereas vascular smooth muscle cells (VSMC) which only expressed AT1 receptor, displayed a clear AT1-dependent proliferative response to AngII. These data demonstrate that cultured human adult fibroblasts express both AT1 and AT2 receptor types and this phenomenon is associated with a lack of growth or collagen synthesis responses to AngII.
PB Elsevier Science Direct
SN 0196-9781
YR 2005
FD 2005-09
LK https://hdl.handle.net/20.500.14352/114105
UL https://hdl.handle.net/20.500.14352/114105
LA eng
NO Galindo M, Santiago B, Palao G, Gutierrez-Cañas I, Ramirez JC, Pablos JL. Coexpression of AT1 and AT2 receptors by human fibroblasts is associated with resistance to angiotensin II. Peptides. 2005 Sep;26(9):1647-53.
NO Grants 02/0057 and G03/152 from Fondo de Investigacion Sanitaria (Spain).
DS Docta Complutense
RD 10 abr 2025