%0 Journal Article
%A Román González, Elvira
%A Huertas, Blanca
%A Prieto, Daniel
%A Díez Orejas, Rosalía María
%A Pla Alonso, Jesús
%T TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
%D 2018
%@ 1746-0921
%U https://hdl.handle.net/20.500.14352/13365
%X AIMTo investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut.MATERIALS & METHODSWe used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines.RESULTSThe colonization rates reached with the TUP1-RFP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed.CONCLUSIONBlockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse.
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