RT Journal Article
T1 TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
A1 Román González, Elvira
A1 Huertas, Blanca
A1 Prieto, Daniel
A1 Díez Orejas, Rosalía María
A1 Pla Alonso, Jesús
AB AIMTo investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut.MATERIALS & METHODSWe used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines.RESULTSThe colonization rates reached with the TUP1-RFP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed.CONCLUSIONBlockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse.
PB Future Medicine
SN 1746-0921
YR 2018
FD 2018-06-01
LK https://hdl.handle.net/20.500.14352/13365
UL https://hdl.handle.net/20.500.14352/13365
LA eng
NO Román González, E., Huertas, B., Prieto, D. et al. «TUP1 -Mediated Filamentation in Candida Albicans Leads to Inability to Colonize the Mouse Gut». Future Microbiology, vol. 13, n.o 8, junio de 2018, pp. 857-67. DOI.org (Crossref), https://doi.org/10.2217/fmb-2018-0012.
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 6 abr 2025