RT Journal Article
T1 Induction of cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation by chloramine-T in male rat liver
A1 Martínez Caballero, María Aranzazu
A1 Ares Lombán, Irma
A1 Rodríguez, Jose Luis
A1 Martínez Caballero, Marta
A1 Martínez Larrañaga, María Rosa
A1 Anadón Navarro, Arturo Ramón
AB Chloramine-T is an antimicrobial agent recognized for its disinfectant properties widely used in food industry. As an N-chloro-compound, chloramine-T contains electrophilic chlorine and in water it hydrolyses to hypochlorite. Chlorine as hypochlorous acid or hypochlorite is a very reactive chemical which can function as both an oxidant and halogenating agent. Because chloramine-T could be involved in the metabolic activation of drugs, in the present study the effects of chloramine-T on the activities of some drug metabolizing enzymes in rat liver microsomes and peroxisome proliferation were determined in vivo. Rats were treated orally with chloramine-T at doses of 1.25, 2.50, 5 and 10 mg/kg body weight (bw)/day for 6 days. The activities of CYP2E1, CYP1A1/2 CYP2B1/2, CYP3A4 and CYP4A1/2 enzymes significantly increased after treatment with 2.50, 5 and 10 mg/kg bw/day, in a dose-dependent manner as compared to control. This effect was not observed after chloramine-T treatment at dose of 1.25 mg/kg bw/day. Our results suggest that chloramine-T may potentiate the toxicity of many xenobiotics via metabolic activation and/or accumulation of reactive metabolites
PB Elsevier
SN 0278-6915
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/98039
UL https://hdl.handle.net/20.500.14352/98039
LA eng
NO Martínez MA, Ares I, Rodríguez JL, Martínez M, Martínez-Larrañaga MR, Anadón A. Induction of cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation by chloramine-T in male rat liver. Food Chem Toxicol. 2017 Aug;106(Pt A):86-91. doi: 10.1016/j.fct.2017.05.012. Epub 2017 May 9. PMID: 28499825
NO Comunidad de Madrid
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 5 abr 2025