RT Journal Article
T1 Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin
A1 Garrido Novelle, Marta
A1 Vázquez, María
A1 Martinello, Kátia
A1 Sánchez-Garrido, Miguel
A1 Tena-Sempere, Manuel
A1 Diéguez, Carlos
AB It is currently accepted that ambient, non-genetic factors influence perinatal development and evoke structural and functional changes that may persist throughout life. Overfeeding and androgenization after birth are two of these key factors that could result in “metabolic imprinting” of neuronal circuits early in life and, thereby, increase the body weight homeostatic “set point”, stimulate appetite and result in obesity. Our aim was to determine the influence of these obesogenic factors on the response to ghrelin. We observed the expected orexigenic effect of ghrelin regardless of the nutritional or hormonal manipulations to which the animals were subjected to at early postnatal development and this effect remained intact at later stages of development. In fact, ghrelin responses increased significantly when the animals were subjected to one of the two manipulations, but not when both were combined. An increased response to ghrelin could explain the obese phenotype displayed by individuals with modified perinatal environment.
PB Nature
SN 2045-2322
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/94795
UL https://hdl.handle.net/20.500.14352/94795
LA eng
NO Novelle, M., Vázquez, M., Martinello, K. et al. Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin. Sci Rep 4, 4855 (2014). https://doi.org/10.1038/srep04855
NO Ministerio de Educación y Ciencia (España)
NO Instituto de Salud Carlos III
NO European Commission
DS Docta Complutense
RD 21 abr 2025