RT Journal Article
T1 Absence of allelic imbalance involving EMSY, CAPNS, and PAK1 genes in papillary thyroid carcinoma
A1 Hidalgo Pascual, Manuel
A1 Martínez Tello, Francisco José
A1 Ferrero Herrero, Eduardo
A1 Labalde Martínez, María
A1 Rigopoulou, Demetra
A1 Ballestín Carcavilla, Claudio
A1 Ramírez Lorca, R.
AB Papillary thyroid cancer (PTC) accounts for 80% of all thyroid malignancies, and genetic alterations associated to its etiology remain largely unknown. Chromosomal band 11q13 seems to be one of the most frequently amplified regions in human cancer, providing several candidate genes that need detailed characterization. The aim of our study was to investigate the existence of allelic imbalance at EMSY, CAPN5, and PAK1, as candidate genes within 11q13.5-q14 region using a single nucleotide polymorphism-based analysis. We selected a panel of 9 polymorphisms that were analyzed in 41 thyroid carcinoma samples, their contralateral non-pathological tissue and 178 controls from the general population. We did not detect allelic imbalance at these loci in our series. However, we observed a difference in the EMSY-haplotype distribution among PTC patients when compared to controls (odds ratio=2.00; p=0.02). We conclude that 11q13.5-q14 is not imbalanced in PTC, but there is evidence suggesting that EMSY might be of relevance in PTC etiology.
PB Springer
SN 0391-4097
YR 2008
FD 2008-07-01
LK https://hdl.handle.net/20.500.14352/98978
UL https://hdl.handle.net/20.500.14352/98978
LA eng
NO Hidalgo M, Saez ME, Martinez-Tello FJ, Moron FJ, Ferrero-Herrero E, Labalde-Martinez M, Rigopoulou D, Ballestin-Carcavilla C, Ruiz A, Royo JL, Ramirez-Lorca R. Absence of allelic imbalance involving EMSY, CAPN5, and PAK1 genes in papillary thyroid carcinoma. J Endocrinol Invest. 2008 Jul;31(7):618-23. doi: 10.1007/BF03345613. PMID: 18787380.
NO Fundación de Investigación Biomédica Mutua Madrileña Automovilista
NO Ministerio de Ciencia y Tecnología
DS Docta Complutense
RD 9 abr 2025