RT Journal Article
T1 Profiles of Volatile Biomarkers Detect Tuberculosis from Skin
A1 Vishinkin, Rotem
A1 Busool, Rami
A1 Mansour, Elias
A1 Fish, Falk
A1 Esmail, Ali
A1 Kumar, Parveen
A1 Gharaa, Alaa
A1 Cancilla, John C
A1 Torrecilla Velasco, José Santiago
A1 Skenders, Girts
A1 Leja, Marcis
A1 Dheda, Keertan
A1 Singh, Sarman
A1 Haick, Hossam
AB Tuberculosis (TB) is an infectious disease that threatens >10 million people annually. Despite advances in TB diagnostics, patients continue to receive an insufficient diagnosis as TB symptoms are not specific. Many existing biodiagnostic tests are slow, have low clinical performance, and can be unsuitable for resource-limited settings. According to the World Health Organization (WHO), a rapid, sputum-free, and cost-effective triage test for real-time detection of TB is urgently needed. This article reports on a new diagnostic pathway enabling a noninvasive, fast, and highly accurate way of detecting TB. The approach relies on TB-specific volatile organic compounds (VOCs) that are detected and quantified from the skin headspace. A specifically designed nanomaterial-based sensors array translates these findings into a point-of-care diagnosis by discriminating between active pulmonary TB patients and controls with sensitivity above 90%. This fulfills the WHO's triage test requirements and poses the potential to become a TB triage test.
PB Wiley-VCHGmbH
YR 2021
FD 2021-08-01
LK https://hdl.handle.net/20.500.14352/129972
UL https://hdl.handle.net/20.500.14352/129972
LA eng
NO Vishinkin, Rotem, et al. «Profiles of Volatile Biomarkers Detect Tuberculosis from Skin». Advanced Science, vol. 8, n.o 15, agosto de 2021, p. 2100235. DOI.org (Crossref), https://doi.org/10.1002/advs.202100235.
NO Fundación Bill y Melinda Gates
NO Fundación Ariane de Rothschild
DS Docta Complutense
RD 20 ene 2026