RT Journal Article
T1 Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus
A1 Carracedo Añón, Julia María
A1 Alique, Matilde
A1 Ramírez Carracedo, Rafael
A1 Bodega, Guillermo
A1 Ramírez, Rafael
AB Endothelial senescence-associated with aging or induced prematurely in pathological situations, such as diabetes, is a first step in the development of Cardiovascular Disease (CVDs) and particularly inflammatory cardiovascular diseases. The main mechanism that links endothelial senescence and the progression of CVDs is the production of altered Extracellular Vesicles (EVs) by senescent endothelial cells among them, Microvesicles (MVs). MVs are recognized as intercellular signaling elements that play a key role in regulating tissue homeostasis. However, MVs produced by damage cell conveyed epigenetic signals, mainly involving microRNAs, which induce many of the injured responses in other vascular cells leading to the development of CVDs. Many studies strongly support that the quantification and characterization of the MVs released by senescent endothelial cells may be useful diagnostic tools in patients with CVDs, as well as a future therapeutic target for these diseases. In this review, we summarize the current knowledge linking senescence-associated MVs to the development of CVDs and discuss the roles of these MVs, in particular, in diabetic-associated increases the risk of CVDs.
PB Bentham Science Publishers
SN 1570-1611
YR 2019
FD 2019-08-01
LK https://hdl.handle.net/20.500.14352/125892
UL https://hdl.handle.net/20.500.14352/125892
LA eng
NO Carracedo, J., Alique, M., Ramírez-Carracedo, R., Bodega, G., & Ramírez, R. (2019). [Rev. of Tendothelial extracellular vesicles produced by senescent cells: Pathophysiological role in the cardiovascular disease associated with all types of diabetes mellitus]. Current Vascular Pharmacology, 17(5), 447-454. https://doi.org/10.2174/1570161116666180820115726
NO This work was supported by Plan Nacional Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII) Fondos Feder European Grants (PI14/00806, PI17/01029), Junta de Andalucía Grants (P12-CTS-7352), Santander-UCM Grants (PR41/17-20964), UAH-GP2018-4. Red de Investigación Renal (REDinREN; RD16/0009/0034). Rafael Ramírez-Carracedo is a fellow of the program FPI (Formación de Personal Investigador) from Universidad Francisco de Vitoria, Madrid, Spain.
NO Instituto de Salud Carlos III
NO European Commission
NO Junta de Andalucía
NO Universidad Complutense de Madrid
NO Banco de Santander
NO Universidad de Alcalá de Henares
NO Universidad Francisco de Vitoria
DS Docta Complutense
RD 18 jul 2026