RT Journal Article
T1 Assessment of In Vitro Release Testing Methods for Colloidal Drug Carriers: The Lack of Standardized Protocols
A1 Gómez Lázaro, Laura
A1 Martín Sabroso, Cristina
A1 Aparicio Blanco, Juan
A1 Torres Suárez, Ana Isabel
AB Although colloidal carriers have been in the pipeline for nearly four decades, standardized methods for testing their drug-release properties remain to be established in pharmacopeias. The in vitro assessment of drug release from these colloidal carriers is one of the most important parameters in the development and quality control of drug-loaded nano- and microcarriers. This lack of standardized protocols occurs due to the difficulties encountered in separating the released drug from the encapsulated one. This review aims to compare the most frequent types of release testing methods (i.e., membrane diffusion techniques, sample and separate methods and in situ detection techniques) in terms of the advantages and disadvantages of each one and of the key parameters that influence drug release in each case.
PB MDPI
SN 1999-4923
YR 2024
FD 2024-01-12
LK https://hdl.handle.net/20.500.14352/112167
UL https://hdl.handle.net/20.500.14352/112167
LA eng
NO Gómez-Lázaro, L.; Martín-Sabroso, C.; Aparicio-Blanco, J.; Torres-Suárez, A.I. Assessment of In Vitro Release Testing Methods for Colloidal Drug Carriers: The Lack of Standardized Protocols. Pharmaceutics 2024, 16, 103. https://doi.org/10.3390/pharmaceutics16010103
NO 2023 Descuento MDPI
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 6 abr 2025