RT Journal Article T1 Real-Time 3D PET Image with Pseudoinverse Reconstruction A1 López Montes, Alejandro A1 Galve Lahoz, Pablo A1 Udías Moinelo, José Manuel A1 Cal-González, Jacobo A1 Vaquero, Juan José A1 Desco, Manuel A1 López Herraiz, Joaquín AB Real-time positron emission tomography (PET) may provide information from first-shot images, enable PET-guided biopsies, and allow awake animal studies. Fully-3D iterative reconstructions yield the best images in PET, but they are too slow for real-time imaging. Analytical methods such as Fourier back projection (FBP) are very fast, but yield images of poor quality with artifacts due to noise or data incompleteness. In this work, an image reconstruction based on the pseudoinverse of the system response matrix (SRM) is presented. w. To implement the pseudoinverse method, the reconstruction problem is separated into two stages. First, the axial part of the SRM is pseudo-inverted (PINV) to rebin the 3D data into 2D datasets. Then, the resulting 2D slices can be reconstructed with analytical methods or by applying the pseudoinverse algorithm again. The proposed two-step PINV reconstruction yielded good-quality images at a rate of several frames per second, compatible with real time applications. Furthermore, extremely fast direct PINV reconstruction of projections of the 3D image collapsed along specific directions can be implemented. PB MDPI SN 2076-3417 YR 2020 FD 2020-04-19 LK https://hdl.handle.net/20.500.14352/8105 UL https://hdl.handle.net/20.500.14352/8105 LA eng DS Docta Complutense RD 10 may 2025