RT Journal Article
T1 Periodic Signal Transmission through Metabolic Pathways with Michaelian Kinetics
A1 Rodríguez, Yoel
A1 Sánchez Torralba, Antonio
A1 Montero Carnerero, Francisco
AB The propagation of oscillations in metabolite concentrations mediated by simple Michaelis−Menten enzymes is studied from a theoretical viewpoint. Sinusoidal input waves are investigated, and the resulting output velocities are analyzed. As a first approach, both irreversible and reversible reactions with linear kinetics are examined. Analytical expressions result for the ratios of output to input amplitudes (damping factors), as well as for phase shifts. It is shown that transmission of sinusoidal oscillations by Michaelis enzymes is approximately linear around the mean input flux even for high amplitudes of the velocity. Accordingly, contributions of superior harmonics to the overall waveform can be neglected. The predicted maximum phase shift for these systems is a quarter of a cycle per reaction step, which occurs at high frequencies. Effective rate constants are introduced that are needed for the accurate prediction of output amplitudes. By using them, calculations are presented suggesting that complete transmission can be expected for low- or medium-saturated glycolytic enzymes.
PB ACS Publications
SN 1520-6106
YR 2002
FD 2002
LK https://hdl.handle.net/20.500.14352/116872
UL https://hdl.handle.net/20.500.14352/116872
LA eng
NO Rodríguez, Yoel, et al. «Periodic Signal Transmission through Metabolic Pathways with Michaelian Kinetics». The Journal of Physical Chemistry B, vol. 106, n.o 21, mayo de 2002, pp. 5536-42. DOI.org (Crossref), https://doi.org/10.1021/jp013391s.
NO DGICYT
NO Ministerio de Ciencia y Tecnologı́a
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 5 abr 2025