RT Journal Article
T1 Gender differences in incidence and in-hospital outcomes of community-acquired, ventilator-associated and nonventilator hospital-acquired pneumonia in Spain
A1 López De Andrés, Ana Isabel
A1 Albaladejo Vicente, Romana
A1 Miguel Díez, Javier De
A1 Hernández Barrera, Valentín
A1 Zichen, Ji
A1 Zamorano León, José Javier
A1 López Herrán, Marta
A1 Carabantes Alarcón, David
A1 Jiménez García, Rodrigo
AB Aims: We aim to compare the incidence and in-hospital outcomes of communityacquired pneumonia (CAP), ventilator-associated pneumonia (VAP) and nonventilator hospital-acquired pneumonia (NV-HAP) according to gender.Methods: This was a retrospective observational epidemiological study using the Spanish National Hospital Discharge Database for the years 2016 and 2017.Results: Of 277 785 hospital admissions, CAP was identified in 257 455 (41.04% females), VAP was identified in 3261 (30.42% females) and NV-HAP was identified in 17 069 (36.58% females). The incidence of all types of pneumonia was higher amongst males (CAP: incidence rate ratio [IRR] 1.05, 95% CI 1.03-1.06; VAP: IRR 1.36, 95% CI 1.26-1.46; and NV-HAP: IRR 1.16, 95% CI 1.14-1.18). The crude in-hospital mortality (IHM) rate for CAP was 11.44% in females and 11.80% in males (P = .005); for VAPIHM, the rate was approximately 35% in patients of both genders and for NV-HAP IHM, the rate was 23.97% for females and 26.40% for males (P < .001). After multivariable adjustment, in patients of both genders, older age and comorbidities were factors associated with IHM in the three types of pneumonia analysed. Female gender was a risk factor for IHM after VAP (OR 1.24; 95% CI 1.06-1.44), and no gender differences were found for CAP or NV-HAP.Conclusions: Our findings show a difference between females and males, with females presenting a lower incidence of all types of pneumonia. However, female gender was a risk factor for IHM after VAP.
PB WILEY
SN 2374-4235
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/101515
UL https://hdl.handle.net/20.500.14352/101515
LA eng
NO López-de-Andrés A, Albaladejo-Vicente R, de Miguel-Diez J, Hernández-Barrera V, Ji Z, Zamorano-León JJ, Lopez-Herranz M, Carabantes Alarcon D, Jimenez-Garcia R. Gender differences in incidence and in-hospital outcomes of community-acquired, ventilator-associated and nonventilator hospital-acquired pneumonia in Spain. Int J Clin Pract. 2021 Mar;75(3):e13762. doi: 10.1111/ijcp.13762
NO Unión Europea
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 30 dic 2025