RT Journal Article
T1 Influence of Chronic Ocular Hypertension on Emmetropia: Refractive, Structural and Functional Study in Two Rat Models
A1 Mendez-Martínez, Silvia
A1 Martínez-rincón, Teresa
A1 Subías, Manuel
A1 Pablo, Luis E
A1 García Herranz, David
A1 García Feijoo, Julián
A1 Bravo Osuna, Irene
A1 Herrero Vanrell, María Del Rocío
A1 García-Martín, Elena
A1 Rodrigo, María Jesús
AB Chronic ocular hypertension (OHT) influences on refraction in youth and causes glaucoma in adulthood. However, the origin of the responsible mechanism is unclear. This study analyzes the effect of mild-moderate chronic OHT on refraction and neuroretina (structure and function) in young-adult Long-Evans rats using optical coherence tomography and electroretinography over 24 weeks. Data from 260 eyes were retrospectively analyzed in two cohorts: an ocular normotension (ONT) cohort (<20 mmHg) and an OHT cohort (>20 mmHg), in which OHT was induced either by sclerosing the episcleral veins (ES group) or by injecting microspheres into the anterior chamber. A trend toward emmetropia was found in both cohorts over time, though it was more pronounced in the OHT cohort (p < 0.001), especially in the ES group (p = 0.001) and males. IOP and refraction were negatively correlated at week 24 (p = 0.010). The OHT cohort showed early thickening in outer retinal sectors (p < 0.050) and the retinal nerve fiber layer, which later thinned. Electroretinography demonstrated early supranormal amplitudes and faster latencies that later declined. Chronic OHT accelerates emmetropia in Long–Evans rat eyes towards slowly progressive myopia, with an initial increase in structure and function that reversed over time.
YR 2021
FD 2021-08-17
LK https://hdl.handle.net/20.500.14352/117978
UL https://hdl.handle.net/20.500.14352/117978
LA eng
NO Mendez-Martinez, S.; Martínez-Rincón, T.; Subias, M.; Pablo, L.E.; García-Herranz, D.; Feijoo, J.G.; Bravo-Osuna, I.; Herrero-Vanrell, R.; Garcia-Martin, E.; Rodrigo, M.J. Influence of Chronic Ocular Hypertension on Emmetropia: Refractive, Structural and Functional Study in Two Rat Models. J. Clin. Med. 2021, 10, 3697. https:// doi.org/10.3390/jcm10163697
NO Instituto de Salud Carlos III
NO Comisión Europea
DS Docta Complutense
RD 17 abr 2025