RT Journal Article
T1 Glomerular Hematuria: Cause or Consequence of Renal Inflammation?
A1 Sevillano, Ángel
A1 Gutiérrez, Eduardo
A1 Guerrero-Hue, Melania
A1 Vázquez-Carballo, Cristina
A1 Yuste, Claudia
A1 Herencia, Carmen
A1 García-Caballero, Cristina
A1 Praga Terente, Manuel
A1 Egido, Jesús
AB Glomerular hematuria is a cardinal symptom of renal disease. Glomerular hematuria may be classified as microhematuria or macrohematuria according to the number of red blood cells in urine. Recent evidence suggests a pathological role of persistent glomerular microhematuria in the progression of renal disease. Moreover, gross hematuria, or macrohematuria, promotes acute kidney injury (AKI), with subsequent impairment of renal function in a high proportion of patients. In this pathological context, hemoglobin, heme, or iron released from red blood cells in the urinary space may cause direct tubular cell injury, oxidative stress, pro-inflammatory cytokine production, and further monocyte/macrophage recruitment. The aim of this manuscript is to review the role of glomerular hematuria in kidney injury, the role of inflammation as cause and consequence of glomerular hematuria, and to discuss novel therapies to combat hematuria.
PB MDPI
SN 1422-0067
YR 2019
FD 2019-05-05
LK https://hdl.handle.net/20.500.14352/12599
UL https://hdl.handle.net/20.500.14352/12599
LA spa
NO Ministerio de Economía y Competitividad (MINECO)
NO Instituto de Salud Carlos III (ISCIII) / FEDER
NO Instituto de Salud Carlos III (ISCIII)/RETIC/FEDER
NO Comunidad de Madrid
DS Docta Complutense
RD 6 abr 2025